Laboratory for biological monitoring and molecular-genetic research

Perunova Nataliya Borisovna Head of the laboratory is Perunova Nataliya Borisovna, MD, professor of the RAS. The author of 110 scientific works, including 4 monographs and 6 study guides, holder of 6 invention patents of the Russian Federation.

Research interests: symbiosis, infectious symbiology, the role of microbial factor in the human health and pathology, microsymbiocenosis, “self/non-self” microbial detection.

Main trends of scientific activity: study of the mechanisms of formation and functioning of microsymbiocenoses, integrative interactions with human organism under the conditions of associative symbiosis.

The most important results of scientific investigations:

  • infection process has been analyzed as the associative symbiosis model system, which includes 3 functional vectors of symbiont interaction: 1) host – dominant partner; 2) host – associative partners; 3) dominant microflora – associative microorganisns (microsymbiocenose). The presence of associant microorganisms in associative symbiosis is multivalued for microsymbiocenose: from the enhancement of the normal flora of the body to the associant antagonism (interference, dominant microsymbiont displacement) with the development of dysbiosis.

  • Investigating of infection from the standpoint of symbiology allowed to determine basic physiological functions of microorganisms (growth/reproduction, persistence) and their most meaningful criteria (bacterial count, antilysozime activity and biofilm formation capacity), which are significant for the development of microsymbiocenose, as well as for the functioning of “host-dominant partner” and “host-associative partners” vectors.
  • The algorithm of self/non-self microbial recognition in the microsymbiocenosis of human intestine has been created on the basis of the contrary phenomena (increase/decrease) related with physiological reproduction and adaptation criteria of microsymbiont “dominant/associant” pair. Metabolites of bifidoflora had an oppositional effect on the reproductive function of the dominant microflora (increase) and the associative microflora (decrease).

  • The bifidoflora has been determined to be the key regulator of the human intestine homeostasis. It finds alien information with the use of self/non-self bacterial recognition and initiates ‘signalling’ of the immune homeostasis biotope regulation through dendrite cells.