Laboratory for cellular symbiosis

Gritsenko Victor Alexandrovich Head of the laboratory is Gritsenko Victor Alexandrovich, M.D., professor, author of more than 300 scientific works, including 3 monographs, holder of 14 patents for invention of the Russian Federation.

Research interests: genetic and phenotypic polymorphisms, bacterial pathogenicity and ecology, etiology and pathogeny of endogenous infections.

 Main trends of scientific activity of the laboratory: investigation of etiological and pathogenic peculiarities of endogenous bacterial infections and analysis of the role of the persistence characteristics of causative agents in their development; development and introduction of novel methods of diagnostics, treatment and prophylaxis of the endogenous bacterial infections into clinical practice.

The most important results of scientific investigations:

  • it has become possible to prove the fundamental character of the endogenous bacterial infections (EBI) as it is a widely spread inflammatory infection caused by associative (commensal) microflora of the macroorganism. The nosological variability of endogenous inflammatory infections has been described and it has been proposed to divide them into two groups: localized (local) and generalized (systematic) endogenous infections. The universal concept of EBI pathogenesis has been elaborated along with the description of the key phases of its development. The classification of endogenous and exogenous risk factors for the development of this pathology has been presented, among which the most pathogenically significant: exposure to stress, dysbiotic microflora disorders, and the presence of compromised target organ.

  • The taxonomic range of endogenous inflammatory infection causative agents have been evaluated with the determination of the prioritized pathogen types belonging to enterobacteria and staphylococci, which have certain persistence potential. The associative bacteria pathogenic pattern (bioprofile) has been concluded, which allowed the associative bacteria to conduct all the key phases of pathogenesis and to become EBI causative agents.

By reference to the established etiopathogenetic and clinical microbiological peculiarities of EBI, it has become possible to develop new software for several inflammatory infections diagnostics and prognosis. General principles of EBI treatment and prophylaxis have been described, which also include sanitation of the affected organ, reduction of inflammation, prevention of the potential causative agents translocation from the endogenous sources and elimination of them, removal of the pathology development risk factors.