Laboratory for the research of mechanisms and regulation of bacterial persistence

Kartashova Olga Lvovna Head of the laboratory is Kartashova Olga Lvovna, doctor of biology, associate professor, the author of 248 scientific works, including 2 monographs, the holder of 25 invention patents of the Russian Federation, 6 certificates of registration of computer software.

Research interests: microorganisms, persistence, regulation.

Main trends of scientific activity: detection of the new biological properties of microorganisms liable for persistence, evaluation of their role in human and animal pathologies; identification of the significance of the microorganisms’ persistence in the process of their interaction with the organism innate immunity factors under the conditions of the parasite-host system; study of the influence of biotic and abiotic effects on the persistence properties of microorganisms.

The most important results of scientific investigations:

  • new original methods of persistence properties determination have been developed; the mechanisms of their survival in a carrier state and in case of inflammatory infections have been deciphered. On the basis of significant signs from microorganisms, novel practical approaches to prognostication of the course of microbial inflammatory diseases have been introduced, as well as novel approaches to diagnostics of staphylococci carrier state and microbiological monitoring of aerial environment pollution. The complex of phenotypic and molecular-genetic specifications of microorganisms have been determined to differentiate dominant strains in microbiocenosis of various biotopes; faecium strains, potential as biological drug components have been selected.
  • Pathogenetic significance of persistence specifications of microorganisms in case of their interaction with natural persistence of the organism factors in the course of non-specific inflammatory diseases and staphylococci carrier state have been discovered. Adaptive and reactive changes in pro- and eukaryotic organisms under conditions of their interactions, providing dynamic balance in the eukaryote-prokaryote system, have been determined.

The regulative capacities of the factors of various natures for persistence properties of opportunistic microorganisms have been investigated and the mechanisms of their action have been deciphered. Novel methods of the treatment of inflammatory diseases, including surgical infections of different sites have been developed, as well as new methods of staphylococci carriers’ sanitation. Experimental data on the connection between the structure of antimicrobial compound and its antipersistent effect has been obtained. Reference strain S.aureus with high antilysozime potency has been selected to test the antipersistent capacities of biological substances.